Euro
USD
British Pound
NULL
Product Description
An antitumor antibiotic isolated from Streptomyces verticillus. Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.
Bleomycin sulfate is anantitumor antibiotic that acts as a radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent.
Biovision | 2246 | Bleomycin sulfate DataSheet
Alternate Name/Synonyms: Blenoxane, Bleo, Blexane
Appearance: White solid
Formulation: N/A
CAS Number: 9041-93-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₅₅H₈₄N₁₇O₂₁S₃ · xH₂SO₄
Molecular Weight: 1415.55. x98.08
Cell-Permeable?: No
Purity: ≥90% (A₂ +B₂)
Solubilities: H2O (10 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: An antitumor antibiotic
MDL Number: MFCD00070310
PubChem CID: 46930981
SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
InChi: InChI=1S/C55H83N17O2InChI=1S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21-,22+,23-,24-,25+,29-,30-,34-,35+,36-,37+,38-,39-,40+,41?,42+,43-,53-,54-;/m1./s1
InChi Key: WUIABRMSWOKTOF-PATWWPTKSA-N
