Product Description
CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.
CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.
Biovision | 2613 | CAL-101 (GS-1101) DataSheet
Alternate Name/Synonyms: 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; Idealisib
Appearance: White solid
Formulation: N/A
CAS Number: 870281-82-6
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₁₈FN₇O
Molecular Weight: 415.42
Cell-Permeable?: Yes
Purity: >98% by HPLC
Solubilities: DMSO(~ 25 mg/ml) or EtOH (~ 15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PI3K p110δ inhibitor
MDL Number: N/A
PubChem CID: 11625818
SMILES: CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
InChi: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
InChi Key: IFSDAJWBUCMOAH-HNNXBMFYSA-N