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Product Description
A synthetic peptide that irreversibly inhibits ICE (interleukin-1β converting enzyme, Ki = 0.76 nM) activity. YVAD is the preferred recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-YVAD-FMK is a cell-permeable, irreversible caspase-1 (ICE) inhibitor
Biovision | 1012 | Caspase-1 Inhibitor Z-YVAD-FMK DataSheet
Alternate Name/Synonyms: Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Appearance: Liquid
Formulation: In DMSO (2 mM)
CAS Number: N/A
Structure Available?: No
Peptide sequence: Z-Tyr-Val-Ala-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₃₁H₃₉FN₄O₉
Molecular Weight: 630.7
Cell-Permeable?: Yes
Purity: >99% by HPLC
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: Caspase-1 inhibitor
MDL Number: N/A
PubChem CID: 16760349
SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2
InChi: InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32) 15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21- 8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34, 40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1
InChi Key: MVPQJUFFTWWKBT-UYDLRUHXSA-N
