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Product Description
A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-LEED-FMK is a cell-permeable, irreversible caspase-13 inhibitor.
Biovision | 1115 | Caspase-13 Inhibitor LEED-FMK DataSheet
Alternate Name/Synonyms: Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone)
Appearance: Liquid
Formulation: DMSO (2 mM)
CAS Number: N/A
Structure Available?: No
Peptide sequence: Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₃₂H₄₅FN₄O₁₂
Molecular Weight: 696.7
Cell-Permeable?: Yes
Purity: >95% by HPLC
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A caspase-13 inhibitor
MDL Number: MFCD03453602
PubChem CID: 44135223
SMILES: CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CCC(=O)OC)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C32H45FN4O12/c1-19(2)15-24(37-32(45)49-18-20-9-7-6-8-10-20)31(44)35-21(11-13-26(39)46-3)29(42)34-22(12-14-27(40)47-4)30(43)36-23(25(38)17-33)16-28(41)48-5/h6-10,19,21-24H,11-18H2,1-5H3,(H,34,42)(H,35,44)(H,36,43)(H,37,45)
InChi Key: JQWJGEBRHHCICO-UHFFFAOYSA-N
