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Product Description
Ready-to-use colorimetric substrate for CPP32/caspase-3 and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly (ADP-ribose) polymerase (PARP). CPP32 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleavage from the peptide substrate DEVD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amounts of caspase assays.
Caspase-3 Substrate DEVD-pNA is a ready-to-use fluorometric substrate for caspase-3/CPP32 (Km = 9.7 µM) and related caspases that recognize the amino acid sequence DEVD.
Biovision | 1008 | Caspase-3 Substrate DEVD-pNA DataSheet
Alternate Name/Synonyms: Ac-DEVD-pNA, Caspase-3 Substrate, Colorimetric
Appearance: Liquid
Formulation: In DMSO ( 4 mM)
CAS Number: N/A
Structure Available?: No
Peptide sequence: Ac-Asp-Glu-Val-Asp-pNA
Salt Form: No
Molecular Formula: C₂₆H₃₄N₆O₁₃
Molecular Weight: 638.58
Cell-Permeable?: No
Purity: >98% by HPLC
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: Caspase-3 substrate
MDL Number: MFCD00792707
PubChem CID: 4329
SMILES: CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
InChi: InChI=1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)
InChi Key: GGXRLUDNGFFUKI-UHFFFAOYSA-N
