Euro
USD
British Pound
NULL
Product Description
CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Cat. No.1759 in preclinical models of pancreatic cancer.
CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death.
Biovision | B2036 | CBL0137 DataSheet
Alternate Name/Synonyms: 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]-bis-ethanone; Curaxin 137
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1197996-80-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₄N₂O₂
Molecular Weight: 336.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Facilitates chromatin transcription (FACT) Inhibitor
MDL Number: N/A
PubChem CID: 44519124
SMILES: CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C
InChi: InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8,11-13,22H,9-10H2,1-4H3
InChi Key: JKCSODVERGVDLT-UHFFFAOYSA-N
