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Product Description
E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. A very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition and displays low toxicity.
E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain.
Biovision | 1739 | E-64 DataSheet
Alternate Name/Synonyms: trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide
Appearance: White crystalline solid
Formulation: N/A
CAS Number: 66701-25-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₂₇N₅O₅
Molecular Weight: 357.41
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (25 mg/ml) or H₂O (20 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A cysteine protease inhibitor
MDL Number: MFCD00080261
PubChem CID: 439487
SMILES: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
InChi: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1
InChi Key: LTLYEAJONXGNFG-HBNTYKKESA-N
