Euro
USD
British Pound
NULL
Product Description
An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
Emetine dihydrochloride is an alkaloid, derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
Biovision | B2339 | Emetine dihydrochloride hydrate DataSheet
Alternate Name/Synonyms: (2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine, dihydrochloride, hydrate,Emetine hydrochloride hydrate
Appearance: White to off-white solid
Formulation:
CAS Number: 7083-71-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₉H₄₀N₂O₄.2HCl. xH₂O
Molecular Weight: 553.56 (anhydrous basis)
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: >100 mg/ml (H₂O) in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A protein synthesis inhibitor
MDL Number: MFCD00149309
PubChem CID: 201899
SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl
InChi: InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
InChi Key: IZTPMTAWOCEKKM-VXMYZLRESA-N
