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Product Description
EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.
EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.
Biovision | 9410 | EPZ-015666 DataSheet
Alternate Name/Synonyms: N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide; GSK3235025
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1616391-65-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₅N₅O₃
Molecular Weight: 383.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective PRMT5 inhibitor
MDL Number: N/A
PubChem CID: 90241673
SMILES: C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O
InChi: InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1
InChi Key: ZKXZLIFRWWKZRY-KRWDZBQOSA-N
