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Product Description
EW-7197 is a potent ALK5 (TGF-β Type I receptor) inhibitor that displays anti metastatic activity in vivo. In vivo mice experiments show EW-7197 repeals TGF- β1 induced tumor cell migration and invasion inhibiting breast cancer metastasis to the lung. It prolongs the life span of BALB/c4T1 mice by inhibiting metastasis and enhancing the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotropic grafted mice.
EW-7197 is a potent ALK5 (TGF-β Type I receptor) inhibitor that displays anti metastatic activity in vivo. In vivo mice experiments show EW-7197 repeals TGF- β1 induced tumor cell migration and invasion inhibiting breast cancer metastasis to the lung. It prolongs the life span of BALB/c4T1 mice by inhibiting metastasis and enhancing the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotropic grafted mice.
Biovision | B1191 | EW-7197 DataSheet
Alternate Name/Synonyms: N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline
Appearance: White Solid
Formulation: N/A
CAS Number: 1352608-82-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₁₈FN₇
Molecular Weight: 399.42
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>75 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent ALK5 inhibitor
MDL Number:
PubChem CID: 54766013
SMILES: CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
InChi: InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
InChi Key: FJCDSQATIJKQKA-UHFFFAOYSA-N
