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Product Description
A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
EZSolution™ Calpain Inhibitor I, ALLN is a 10 mM (5 mg in 1304 µl) of Calpain Inhibitor ALLN (Cat.No. 1834) in anhydrous DMSO.
Biovision | 2544 | EZSolutioin™ Calpain Inhibitor I, ALLN DataSheet
Alternate Name/Synonyms: Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous ethanol
CAS Number: 110044-82-1
Structure Available?: Yes
Peptide sequence: Ac-Leu-Leu-Nile-CHO
Salt Form: No
Molecular Formula: C₂₀H₃₇N₃O₄
Molecular Weight: 383.54
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: N/A
Handling: Protect from moisture and air
Country of Origin: USA
Tag Line: A Calpain inhibitor
MDL Number: MFCD00065505
PubChem CID: 443118
SMILES: CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C
InChi: InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChi Key: FMYKJLXRRQTBOR-BZSNNMDCSA-N
