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Product Description
Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle
EZSolution™ Cyclopamine is a 10 mM (5 mg in 1215 µl) of Sonic hedgehog (Shh) signaling pathway antagonist Cyclopamine (Cat. No. 1578) in ethanol.
Biovision | 2545 | EZSolution™ Cyclopamine DataSheet
Alternate Name/Synonyms: 11-deoxojervine
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: 4449-51-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₄₁NO₂
Molecular Weight: 411.62
Cell-Permeable?: Yes
Purity: ≥99%
Solubilities: N/A
Handling: Protect from moisture and air
Country of Origin: USA
Tag Line: A hedgehog signaling inhibitor
MDL Number: MFCD01735266
PubChem CID: 442972
SMILES: CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChi Key: QASFUMOKHFSJGL-LAFRSMQTSA-N
