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Product Description
Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.
EZSolution™ SCD1 inhibitor is a 10 mM (1 mg in 258 µl) of SCD1(stearoyl-CoA desaturase 1) inhibitor (Cat. No.1716) in anhydrous DMSO.
Biovision | 2548 | EZSolution™ SCD1 Inhibitor DataSheet
Alternate Name/Synonyms: 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Appearance: Liquid
Formulation: A 10 mM solution in anhydrous DMSO
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₂ClN₃O₃
Molecular Weight: 387.86
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: N/A
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A SCD1(stearoyl-CoA desaturase 1 inhibitor
MDL Number: N/A
PubChem CID: 24905400
SMILES: CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl
InChi: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
InChi Key: DPYTYQFYDLYWHZ-UHFFFAOYSA-N
