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Product Description
Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC₅₀ = ~1 nM).
FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators.
Biovision | 1914 | FK-866 DataSheet
Alternate Name/Synonyms: N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 658084-64-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₉N₃O₂
Molecular Weight: 391.51
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: DMSO (>30 mg/ml) and Ethanol
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)
MDL Number: N/A
PubChem CID: 6914657
SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChi: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13- 17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14, 16-18H2,(H,26,28)/b12-11+
InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N
