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Product Description
Fumagillin is a meroterpenoid antibiotic isolated from Aspergillus fumigatus. An anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.
Fumagillin is an anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression.
Biovision | 2368 | Fumagillin DataSheet
Alternate Name/Synonyms: Amebacilin; Fugilin; Fumidil; Fumadil B; NSC9168; U5762
Appearance: Off-white solid
Formulation: N/A
CAS Number: 23110-15-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₃₄O₇
Molecular Weight: 458.54
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: Ethanol (~ 1 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: An angiogenesis inhibitor
MDL Number: MFCD03990453
PubChem CID: 6917655
SMILES: CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
InChi: InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3, 33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
InChi Key: NGGMYCMLYOUNGM-CSDLUJIJSA-N
