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Product Description
GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It induces ATM kinase activity in A-T cells carrying different homozygous nonsense mutations; this analog is also active in A-T cells containing TAG or TAA stop codons.
GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It induces ATM kinase activity in A-T cells carrying different homozygous nonsense mutations; this analog is also active in A-T cells containing TAG or TAA stop codons.
Biovision | B1842 | GJ-103 Sodium salt DataSheet
Alternate Name/Synonyms: 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate sodium
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1459687-96-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₆H₁₃N₄NaO₃S
Molecular Weight: 364.35
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: H₂O
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: An active, water-soluble analog of the read-through compound GJ072.
MDL Number: N/A
PubChem CID: 71748052
SMILES: COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+]
InChi: InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1
InChi Key: PTFQBXAUOWUATD-UHFFFAOYSA-M
