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Product Description
GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.
GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Biovision | 9450 | GSK-1059615 DataSheet
Alternate Name/Synonyms: 5Z-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione
Appearance: Off-white solid
Formulation: N/A
CAS Number: 958852-01-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₈H₁₁N₃O₂S
Molecular Weight: 333.36
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~4 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, reversible PI3Kα inhibitor
MDL Number: MFCD18074517
PubChem CID: 23582824
SMILES: C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4
InChi: InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-
InChi Key: QDITZBLZQQZVEE-YBEGLDIGSA-N
