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Product Description
GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.
GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.
Biovision | B1089 | GSK-2110183 DataSheet
Alternate Name/Synonyms: N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1047644-62-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₇Cl₂FN₄OS
Molecular Weight: 427.32
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, selective, and ATP-competitive pan-Akt inhibitor
MDL Number: N/A
PubChem CID: 46843057
SMILES: CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl
InChi: InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1
InChi Key: AFJRDFWMXUECEW-LBPRGKRZSA-N
