Euro
USD
British Pound
NULL
Product Description
A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.
GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro).
Biovision | 2260 | GSK-J1 sodium salt DataSheet
Alternate Name/Synonyms: 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate, monosodium salt
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₂₂H₂₂N₅O₂ ∙ Na
Molecular Weight: 411.43
Cell-Permeable?: No
Purity: ≥95%
Solubilities: DMSO
Handling: Protect from light and mositure
Country of Origin: USA
Tag Line: A potent histone demethylase JMJD3/UTX inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: N/A
InChi: N/A
InChi Key: N/A
