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Product Description
GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.
GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.
Biovision | B2278 | GW-4064 DataSheet
Alternate Name/Synonyms: 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
Appearance: White solid
Formulation: N/A
CAS Number: 278779-30-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₂₂Cl₃NO₄
Molecular Weight: 542.84
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective, non-steroidal farnesoid X receptor (FXR) agonist
MDL Number: MFCD09971006
PubChem CID: 9893571
SMILES: CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl
InChi: InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)
InChi Key: BYTNEISLBIENSA-MDZDMXLPSA-N
