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Product Description
A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.
I-BET151 is a BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis.
Biovision | 2220 | I-BET151 DataSheet
Alternate Name/Synonyms: GSK1210151A
Appearance: Beige to pale yellow solid
Formulation: N/A
CAS Number: 1300031-49-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₁N₅O₃
Molecular Weight: 415.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC (≥99.5% optical purity)
Solubilities: DMSO (100 mM) or Ethanol (100 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A BET bromodomain inhibitor
MDL Number: MFCD22124472
PubChem CID: 52912189
SMILES: CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
InChi: InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChi Key: VUVUVNZRUGEAHB-CYBMUJFWSA-N
