Product Description
IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.
IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.
Biovision | 9451 | IOX2 DataSheet
Alternate Name/Synonyms: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Appearance: White solid
Formulation: N/A
CAS Number: 931398-72-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₁₆N₂O₅
Molecular Weight: 352.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2)
MDL Number: MFCD22580424
PubChem CID: 54685215
SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
InChi: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N