Product Description
ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ = 0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ = 0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Biovision | 2879 | ITD-1 DataSheet
Alternate Name/Synonyms: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1099644-42-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₉NO₃
Molecular Weight: 415.52
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~8 mg/ml) or EtOH (~4 mg/ml with warming)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and highly selective TGFβ signaling pathway inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC
InChi: InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3
InChi Key: ULFUJLFTRWWLPO-UHFFFAOYSA-N