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Product Description
Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.
JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.
Biovision | 2534 | JAK Inhibitor, Pyridone 6 DataSheet
Alternate Name/Synonyms: 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one; Pyridone 6; CMP 6
Appearance: Off-white solid
Formulation: N/A
CAS Number: 457081-03-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₆FN₃O
Molecular Weight: 309.3
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent JAK inhibitor
MDL Number: MFCD17019334
PubChem CID: 5494425
SMILES: CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
InChi: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N
