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Product Description
Cell-permeable. A potent , selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold selectivity for FAAH-1 over FAAH-2. Displays analgesic activity in various animal models.
JNJ-1661010 is a potent, selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold selectivity for FAAH-1 over FAAH-2.
Biovision | 2413 | JNJ-1661010 DataSheet
Alternate Name/Synonyms: 4-(3-Phenyl-[1,2,4]- thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 681136-29-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₉N₅OS
Molecular Weight: 365.46
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~25 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A FAAH inhibitor
MDL Number: MFCD00209157
PubChem CID: 2809273
SMILES: C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
InChi: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChi Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N
