Product Description
PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.
PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.
Biovision | 2475 | Jumonji HDM Inhibitor, PBIT DataSheet
Alternate Name/Synonyms: 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
Appearance: White solid
Formulation: N/A
CAS Number: 2514-30-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₁NOS
Molecular Weight: 241.31
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent jumonji HDM inhibitor
MDL Number: MFCD05856231
PubChem CID: 935415
SMILES: CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2
InChi: InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChi Key: KRXMYBAZKJBJAB-UHFFFAOYSA-N