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Product Description
K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle checkpoint, and induces mitotic arrest in cells accompanied by the formation of monopolar spindles.
K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle checkpoint, and induces mitotic arrest in cells accompanied by the formation of monopolar spindles.
Biovision | B1073 | K858 DataSheet
Alternate Name/Synonyms: N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 72926-24-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₁₅N₃O₂S
Molecular Weight: 277.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor
MDL Number: MFCD00181155
PubChem CID: 2930014
SMILES: CC(=O)NC1=NN(C(S1)(C)C2=CC=CC=C2)C(=O)C
InChi: InChI=1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
InChi Key: JEFVYQYZCAVNTP-UHFFFAOYSA-N
