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Product Description
L-Buthionine-(S,R)-Sulfoximine is a potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells.
L-Buthionine-(S,R)-Sulfoximine is a potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells.
Biovision | B2305 | L-Buthionine-(S,R)-Sulfoximine DataSheet
Alternate Name/Synonyms: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 83730-53-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₈H₁₈N₂O₃S
Molecular Weight: 222.3
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: PBS, pH 7.2 (~5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, fast acting, irreversible inhibitor of gamma-glutamylcysteine synthetase
MDL Number: MFCD00067000
PubChem CID: 119565
SMILES: CCCCS(=N)(=O)CCC(C(=O)O)N
InChi: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChi Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N
