Euro
USD
British Pound
NULL
Product Description
Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Biovision | 2016 | LDN-57444 DataSheet
Alternate Name/Synonyms: 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Appearance: Yellow solid
Formulation: N/A
CAS Number: 668467-91-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₁Cl₃N₂O₃
Molecular Weight: 397.64
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective UCHL1 inhibitor
MDL Number: MFCD09037562
PubChem CID: 16760696
SMILES: CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChi: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16) 24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChi Key: OPQRFPHLZZPCCH-PGMHBOJBSA-N
