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Product Description
An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.
Lestaurtinib is a an indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.
Biovision | 1805 | Lestaurtinib DataSheet
Alternate Name/Synonyms: CEP-701; KT-5555; SPM-924
Appearance: Colorless solid
Formulation: N/A
CAS Number: 111358-88-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₁N₃O₄
Molecular Weight: 439.46
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (100 mg/ml) and Ethanol (20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A PTK inhibitor
MDL Number: MFCD12828858
PubChem CID: 126565
SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
InChi: InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
InChi Key: UIARLYUEJFELEN-LROUJFHJSA-N
