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Product Description
MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively. It displays excellent activity of suppressing the replication of WT virus with 95% effective concentration of 20 nM. It also exhibited anti-virus activity against 10 different HIV-1 subtype viruses including K103N, Y81C.
MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC₅₀ values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively.
Biovision | B1250 | MK-1439 DataSheet
Alternate Name/Synonyms: 3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 1338225-97-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₁ClF₃N₅O₃
Molecular Weight: 425.75
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS
MDL Number:
PubChem CID: 58460047
SMILES: CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
InChi: InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
InChi Key: ZIAOVIPSKUPPQW-UHFFFAOYSA-N
