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Product Description
MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.
MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.
Biovision | 9462 | MK-4827 DataSheet
Alternate Name/Synonyms: 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; Niraparib
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 1038915-60-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₂₀N₄O
Molecular Weight: 320.39
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>4 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective PARP-1 and PARP-2 inhibitor
MDL Number: N/A
PubChem CID: 24958200
SMILES: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
InChi: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
InChi Key: PCHKPVIQAHNQLW-CQSZACIVSA-N
