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Product Description
MLN8237 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity.
MLN8237 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity.
Biovision | 2718 | MLN8237 DataSheet
Alternate Name/Synonyms: 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1028486-01-2
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₀ClFN₄O₄
Molecular Weight: 518.9
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent Aurora kinase A inhibitor
MDL Number: N/A
PubChem CID: 24771867
SMILES: COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
InChi: InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
InChi Key: ZLHFILGSQDJULK-UHFFFAOYSA-N
