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Product Description
Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities. Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺+ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.
Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.
Biovision | 9620 | Neomycin sulfate DataSheet
Alternate Name/Synonyms: 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1405-10-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₄₆N₆O₁₃·3H₂SO4
Molecular Weight: 908.9
Cell-Permeable?: Yes
Purity: ≥90%
Solubilities: H₂O (~50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: Abroad spectrum aminoglycoside antibiotic
MDL Number: MFCD00077833
PubChem CID: 44134844
SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi: InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)
InChi Key: KWBUARAINLGYMG-UHFFFAOYSA-N
