Euro
USD
British Pound
NULL
Product Description
NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP.
NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP.
Biovision | 2682 | NSC 405020 DataSheet
Alternate Name/Synonyms: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 7497-07-6
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₂H₁₅Cl₂NO
Molecular Weight: 260.16
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml) or EtOH (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent MT1-MMP inhibitor
MDL Number: N/A
PubChem CID: 346721
SMILES: CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl
InChi: InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
InChi Key: ARDYECYBETXQFD-UHFFFAOYSA-N
