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Product Description
OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. It binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.
OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity.
Biovision | 2372 | OSI-027 DataSheet
Alternate Name/Synonyms: 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; ASP4786
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 936890-98-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₂N₆O₃
Molecular Weight: 406.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~18 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent mTOR inhibitor
MDL Number: MFCD20275101
PubChem CID: 44224160
SMILES: COC1=CC=CC2=CC(=C3C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)N=C21
InChi: InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12H,5-8,22H2,1H3,(H,23,24)(H,28,29)/b17-14-
InChi Key: CDNMDRUIGNHEMR-VKAVYKQESA-N
