Product Description
An extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 25 pM). Inhibits other purified kinases only at micromolar or higher concentrations.
PD 153035 Hydrochloride is an extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 25 pM).
Biovision | 1656 | PD 153035 Hydrochloride DataSheet
Alternate Name/Synonyms: N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride: AG 1517; NSC-669364; SU 5271
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 153436-54-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₄BrN₃O₂.HCl
Molecular Weight: 396.67
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An EGFR inhibitor
MDL Number: MFCD01074805
PubChem CID: 11246488
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
InChi: InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12) 20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
InChi Key: ZJOKWAWPAPMNIM-UHFFFAOYSA-N