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Product Description
PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Shows efficacy in a preclinical model of diabetic nephropathy.
PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Shows efficacy in a preclinical model of diabetic nephropathy.
Biovision | B2033 | PF-06409577 DataSheet
Alternate Name/Synonyms: 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1467057-23-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₆ClNO₃
Molecular Weight: 341.79
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective allosteric AMPK activator
MDL Number: N/A
PubChem CID: 71748255
SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
InChi: InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
InChi Key: FHQXLWCFSUSXBF-UHFFFAOYSA-N
