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Product Description
PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).
PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).
Biovision | B2218 | PF-06840003 DataSheet
Alternate Name/Synonyms: 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione; EOS 200271
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 198474-05-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₂H₉FN₂O₂
Molecular Weight: 232.21
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor
MDL Number: N/A
PubChem CID: 23063810
SMILES: C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F
InChi: InChI=1S/C12H9FN2O2/c13-6-1-2-10-7(3-6)9(5-14-10)8-4-11(16)15-12(8)17/h1-3,5,8,14H,4H2,(H,15,16,17)
InChi Key: MXKLDYKORJEOPR-UHFFFAOYSA-N
