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Product Description
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
Biovision | 9460 | PF-4708671 DataSheet
Alternate Name/Synonyms: 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
Appearance: White solid
Formulation: N/A
CAS Number: 1255517-76-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₂₁F₃N₆
Molecular Weight: 390.41
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A p70 ribosomal S6 kinase inhibitor
MDL Number: MFCD18086922
PubChem CID: 51371303
SMILES: CC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
InChi: InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChi Key: FBLPQCAQRNSVHB-UHFFFAOYSA-N
