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Product Description
PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.
PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.
Biovision | B1837 | PNU-74654 DataSheet
Alternate Name/Synonyms: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydra-zide
Appearance: White solid
Formulation: N/A
CAS Number: 113906-27-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₁₆N₂O₃
Molecular Weight: 320.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A β-catenin inhibitor
MDL Number: N/A
PubChem CID: 60119583
SMILES: CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
InChi: InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)
InChi Key: JJEDWBQZCRESJL-UHFFFAOYSA-N
