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Product Description
PTC-124 has been reported to help the ribosome skip over the premature stop, restore production of functional protein, and thereby potentially treat these genetic diseases. In a mouse model of cystic fibrosis caused by nonsense mutations, PTC-124 treatment has been shown to restore cystic fibrosis transmembrane conductance regulator (CFTR) protein expression and function.
PTC-124 has been reported to help the ribosome skip over the premature stop, restore production of functional protein, and thereby potentially treat these genetic diseases. In a mouse model of cystic fibrosis caused by nonsense mutations, PTC-124 treatment has been shown to restore cystic fibrosis transmembrane conductance regulator (CFTR) protein expression and function.
Biovision | 9421 | PTC-124 DataSheet
Alternate Name/Synonyms: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-benzoic acid
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 775304-57-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₉FN₂O₃
Molecular Weight: 284.24
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: CFTR-G542X nonsense allele inhibitor
MDL Number: MFCD09864996
PubChem CID: 11219835
SMILES: C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F
InChi: InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)
InChi Key: OOUGLTULBSNHNF-UHFFFAOYSA-N
