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Product Description
Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
PYR-41 is an irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Biovision | 1925 | PYR-41 DataSheet
Alternate Name/Synonyms: 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Appearance: Brown solid
Formulation: N/A
CAS Number: 418805-02-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₃N₃O₇
Molecular Weight: 371.3
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~25 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: An irreversible ubiquitin-activating enzyme (E1) inhibitor
MDL Number: N/A
PubChem CID: 5335621
SMILES: CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChi Key: ARGIPZKQJGFSGQ-LCYFTJDESA-N
