Product Description
Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF.
Quizartinib is a second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3).
Biovision | 2008 | Quizartinib DataSheet
Alternate Name/Synonyms: AC220; AC010220
Appearance: Off-white solid
Formulation: N/A
CAS Number: 950769-58-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₂N₆O₄S
Molecular Weight: 560.67
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (~200 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent FLT3 receptor tyrosine kinase inhibitor
MDL Number: MFCD18074524
PubChem CID: 24889392
SMILES: CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6) SC4=N3
InChi: InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChi Key: CVWXJKQAOSCOAB-UHFFFAOYSA-N