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Product Description
Cell-permeable. Selective inhibitor of p38 mitogen-activated protein kinase (MAP Kinase) (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα.
SB 203580 is a selective inhibitor of p38 mitogen-activated protein kinase (MAP Kinase) (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα.
Biovision | 1712 | SB 203580 DataSheet
Alternate Name/Synonyms: [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 152121-47-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₁₆FN₃OS
Molecular Weight: 377.43
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (>50 mg/ml) or warm ethanol (12 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A MAP Kinase inhibitor
MDL Number: MFCD00922198
PubChem CID: 176155
SMILES: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChi: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChi Key: CDMGBJANTYXAIV-UHFFFAOYSA-N
