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Product Description
A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It inhibits ALK4 only at higher concentrations (IC₅₀ = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.
SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It inhibits ALK4 only at higher concentrations (IC₅₀ = 140 nM).
Biovision | 1674 | SB-431542 DataSheet
Alternate Name/Synonyms: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 301836-41-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₁₈N₄O₃
Molecular Weight: 384.39
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (20 mg/ml) or EtOH (2 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: TGF-β1 receptor (ALK5) inhibitor
MDL Number: MFCD11045982
PubChem CID: 4521392
SMILES: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1- 2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25, 26)
InChi Key: FHYUGAJXYORMHI-UHFFFAOYSA-N
