Product Description
SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.
SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.
Biovision | 2766 | SC-79 DataSheet
Alternate Name/Synonyms: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Appearance: White solid
Formulation: N/A
CAS Number: 305834-79-1
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₇ClN₂O₅
Molecular Weight: 364.78
Cell-Permeable?: Y
Purity: ≥98% by TLC
Solubilities: DMSO (~ 100 mg/ml) or EtOH (~ 40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An Akt activator
MDL Number: N/A
PubChem CID: N/A
SMILES: ClC1=CC=C(OC(N)=C(C(OCC)=O)C2C(C#N)C(OCC)=O)C2=C1
InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChi Key: DXVKFBGVVRSOLI-UHFFFAOYSA-N