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Product Description
SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO).
SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO).
Biovision | 2894 | SKF-86002 DataSheet
Alternate Name/Synonyms: 6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
Appearance: Off-white solid
Formulation: N/A
CAS Number: 72873-74-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₂F₃FS
Molecular Weight: 297.35
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A p38 MAP kinase inhibitor
MDL Number: MFCD00869367
PubChem CID: 5228
SMILES: C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChi: InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChi Key: YOELZIQOLWZLQC-UHFFFAOYSA-N
