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Product Description
SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.
SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.
Biovision | 2801 | Smo agonist, SAG dihydrochloride DataSheet
Alternate Name/Synonyms: N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, dihydrochloride
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 364590-63-6
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₂₈ClN₃OS. 2HCl
Molecular Weight: 562.98
Cell-Permeable?: Y
Purity: ≥98% by HPLC
Solubilities: H2O (~ 25 mg/ml) DMSO (~ 10 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A cell-permeable Smoothened (Smo) agonist
MDL Number: N/A
PubChem CID: 71433770
SMILES: CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.O.Cl.Cl
InChi: InChI=1S/C28H28ClN3OS.2ClH.H2O/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;;;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;2*1H;1H2
InChi Key: IYXUQUYRWPGIQL-UHFFFAOYSA-N
