Euro
USD
British Pound
NULL
Product Description
SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Smo Antagonist, SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Biovision | 2159 | Smo Antagonist, SA10 DataSheet
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Cell-Permeable?: Yes
Purity: ≥95% by NMR
Solubilities: DMSO
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A Hedgehog (Hh) signaling pathway antagonist
MDL Number: N/A
PubChem CID: N/A
SMILES: N/A
InChi: N/A
InChi Key: N/A
